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The five most upregulated genes in oligodendrocytes were HSPH1, HSPA1A, HSPB1, PTGES3 and HSP90AA1, while the five most downregulated genes were NAALADL2, MIR219-2, PPP2R2B, PDE1A and POLR2F (Fig

GPs may initiate treatment empirically in such cases, with diagnostic samples ideally taken beforehand where possible

Future research should prioritize standardized, regulator-ready curcumin formulations with defined curcuminoid compositions, release profiles, and mucosal retention (e.g., mucoadhesive films or nanomicelles), accompanied by stability and pharmacokinetic data as well as devicedrug specifications for antimicrobial photodynamic therapy